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Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 248-253 doi: 10.1007/s11684-011-0149-3

Abstract: Arterial remodeling in allografts eventually causes ischemic graft failure.This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including

Keywords： transplantation     chronic rejection     neointimal     immunology     arterial remodeling     allograft vasculopathy    

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Research on the Buffering Effect of Flexible Materialon the Explosive Loading

Yu Shaojuan,Li Yongchi,Liu Haowen,Sun Yuxin, Hu Xiuzhang

Strategic Study of CAE 2007, Volume 9, Issue 4,   Pages 75-78

Abstract: the specific incremental thermal-plastic constitutive relations, combining the simulation of X ray load The thickness of explosive and flexible material that influences the load of the interface is discussed

Keywords： flexible material     explosive loading     load remodeling     numerical simulation    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems and , an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 408-414 doi: 10.1007/s11684-009-0069-7

Abstract: Bone remodeling in orthodontic treatment has been one of the most concerned issues.The purpose of this study was to characterize the changes in bone remodeling on both labial and lingual

Keywords： alveolus     remodeling     orthodontics     extraction    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 60-67 doi: 10.1007/s11684-019-0694-8

Abstract: Bromodomain PHD-finger transcription factor (BPTF) is the largest subunit of the nucleosome remodelingfactor and plays an important role in chromatin remodeling for gene activation through its association

Keywords： BPTF     small molecule     epigenetics     non-small-cell lung cancer    

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Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

Frontiers in Energy 2015, Volume 9, Issue 4,   Pages 472-485 doi: 10.1007/s11708-015-0373-7

Abstract: The composite load is a combination of the static and dynamic load model.To develop this composite load model, the exponential load is used as a static load model and inductionmotors (IMs) are used as a dynamic load model.This aggregate model is used as a dynamic load model.exponential model of static load and for the fifth and third order IM dynamic load model using state

Keywords： isolated hybrid power system (IHPS)     composite load model     static load     dynamic load     induction motor loadmodel     aggregate load    

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Calculation method of load distribution on pipe threaded connections under tension load

Shoujun CHEN, Lianxin GAO, Qi AN

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 2,   Pages 241-248 doi: 10.1007/s11465-011-0219-x

Abstract:

This paper presents a new calculation method that can calculate the load distribution on pipe threadedconnections under tension load.the new method on the sample of P-110S pipe threaded connection, the obtained results show that the loadThe model offers a new way to calculate the loads carried on the thread teeth under tension load.

Keywords： load distribution     calculation method     pipe threaded connections     tension load    

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Comparison of optimal capacitor placement methods in radial distribution system with load growth andZIP load model

Veera Venkata Satya Naryana MURTY, Ashwani KUMAR

Frontiers in Energy 2013, Volume 7, Issue 2,   Pages 197-213 doi: 10.1007/s11708-013-0249-7

Abstract: Furthermore, the load growth factor has been considered in the study which is essential for the planningand expansion of the existing systems, whereas the impact of the realistic load model as ZIP load model

Keywords： load growth     load models     reactive power compensation     radial distribution system     power loss index (PLI)    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 877-894 doi: 10.1007/s11709-021-0756-2

Abstract: bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic loadapproach, the experimental site study yielded MLFs comparable with those directly calculated using traffic loadcaused the proposed approach, existing design specifications, and conventional approach of ignoring lane load

Keywords： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion    

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Shape design of arch dams under load uncertainties with robust optimization

Fengjie TAN, Tom LAHMER

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4,   Pages 852-862 doi: 10.1007/s11709-019-0522-x

Abstract: The optimization of an arch-type dam is realized here by a robust optimization method under load uncertaintyThe load uncertainty is modeled as an ellipsoidal expression.

Keywords： arch dam     shape optimization     robust optimization     load uncertainty     approximation model    

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Prediction of bed load sediments using different artificial neural network models

Reza ASHEGHI, Seyed Abbas HOSSEINI

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 2,   Pages 374-386 doi: 10.1007/s11709-019-0600-0

Abstract: based function (RBF), and generalized feed forward neural network using five dominant parameters of bed load

Keywords： bed load prediction     artificial neural network     modeling     empirical equations    

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A method to predict cooling load of large commercial buildings based on weather forecast and internal

Junbao JIA,Jincheng XING,Jihong LING,Ren PENG

Frontiers in Energy 2016, Volume 10, Issue 4,   Pages 459-465 doi: 10.1007/s11708-016-0424-8

Abstract: characteristics of the higher density and randomness, this paper presented an air-conditioning cooling loadlinear feedback regression model was applied to predict, with precision, the air conditioning cooling loadCase analysis showed that the largest mean relative error of hourly and the daily predicting cooling load

Keywords： commercial building     load prediction     multiple linear regression    

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Influence of axial load on the lateral pile groups response in cohesionless and cohesive soil

Jasim M. ABBASA,Zamri CHIK,Mohd Raihan TAHA

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 2,   Pages 176-193 doi: 10.1007/s11709-015-0289-7

Abstract: curves for lateral single pile response were improved with respect to the influence of increasing axial loadbe used in the evaluation of the lateral pile group action taking into account the effect of axial loadlateral resistance for the pile in the group relative to that for the single pile in case of pure lateral loadWhile, in case of simultaneous combined loads, large axial load intensities (i.e., more than 6 , whereis lateral load values) will have an increase in -multiplier by approximately 100% and will consequently

Keywords： piles     pile group     spacing     configuration     combined load    

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Analysis of load and adaptability of disc cutters during shield tunneling in soft–hard varied strata

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 4,   Pages 533-545 doi: 10.1007/s11709-023-0946-1

Abstract: to numerically simulate the failure process of materials on the excavation face and to calculate the loadThe results of numerical calculation can reflect the load level and the behavior of the disc cutters

Keywords： shield tunneling     disc cutter load     laboratory excavation test     numerical calculation     soft–hard varied    

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Title Author Date Type Operation

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Journal Article

Research on the Buffering Effect of Flexible Materialon the Explosive Loading

Yu Shaojuan,Li Yongchi,Liu Haowen,Sun Yuxin, Hu Xiuzhang

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Journal Article

Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

Journal Article

Calculation method of load distribution on pipe threaded connections under tension load

Shoujun CHEN, Lianxin GAO, Qi AN

Journal Article

Comparison of optimal capacitor placement methods in radial distribution system with load growth andZIP load model

Veera Venkata Satya Naryana MURTY, Ashwani KUMAR

Journal Article

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Journal Article

Shape design of arch dams under load uncertainties with robust optimization

Fengjie TAN, Tom LAHMER

Journal Article

Prediction of bed load sediments using different artificial neural network models

Reza ASHEGHI, Seyed Abbas HOSSEINI

Journal Article

A method to predict cooling load of large commercial buildings based on weather forecast and internal

Junbao JIA,Jincheng XING,Jihong LING,Ren PENG

Journal Article

Influence of axial load on the lateral pile groups response in cohesionless and cohesive soil

Jasim M. ABBASA,Zamri CHIK,Mohd Raihan TAHA

Journal Article

Analysis of load and adaptability of disc cutters during shield tunneling in soft–hard varied strata

Journal Article